dbSAM | Search

Examples: P04637, TP53

Welcome to dbSAM!

dbSAM is a comprehensive database for subcellular localization altering mutations (SAMs). We collected SAMs with different evidence types:

Experimentally validated SAMs: 4,301 mutation-localization associations were manually curated from over 500 literature, including 1,512 SAMs and 2,789 non-SAMs.
Potential SAMs: 2,137,705 potential SAMs were inferred from 8,934,325 million human missense mutations by integrating pSAM/ProtGPS predictions, functional motif annotations, and PTM disruptions.
Pathogenic SAMs: 181,955 pathogenic SAMs that plausibly contribute to subcellular mislocalization were mapped to 3,638 Mendelian diseases and 622 cancer types.

In dbSAM, you can access the following information:

Basic information: protein context including functional description, subcellular localization, and physicochemical properties.
Experimental evidence: detailed validation metadata curated from literature, covering cell lines, subcellular localization assay, change degree, molecular consequence, cellular and functional phenotypes, as well as disease relevance and detailed experimental descriptions.
Comprehensive variant-level annotations:
1. Localization prediction, including localization probabilities and trajectory, and localization-determining region.
2. Functional motif, such as localization signals, LCSs and MIDs of condensate-forming proteins, together with the positional relationship between each variant and these functional motifs.
3. Post-translational modification linkage, listing known PTM sites and whether the variant disrupts these modifications.
4. Disease association, including clinical pathogenicity, related phenotypes, variant deleteriousness scores, and somatic mutation occurrence.

Detailed annotation

Basic information

Experimental evidence

Localization prediction

Functional motif

PTM linkage

Disease association